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KMID : 1134820170460091137
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Journal of the Korean Society of Food Science and Nutrition
2017 Volume.46 No. 9 p.1137 ~ p.1142
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Anti-Visceral Obesity Effect of Apios americana Medikus in Diet-Induced Obese Mice
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Choi Ra-Yeong
Lee Jin
Ryu Hyo-Seon
Ham Ju-Ri
Park Seok-Kyu
Kim Myung-Joo
Lee Mi-Kyung
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Abstract
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This study examined the effects of apios (Apios americana Medikus) supplementation on visceral obesity in high-fat diet-induced obese mice. C57BL/6N mice were fed a high-fat diet (40% calories from fat) with or without apios powder (10%, w/w) for 12 weeks. At the end of the experiment, apios supplementation reduced visceral fat mass significantly by 14.3% compared to the control group. Apios decreased significantly the atherogenic index, serum leptin level, hepatic lipid (free fatty acid and triglyceride) content, and lipid droplets, whereas it increased the serum high density lipoprotein-cholesterol/total cholesterol ratio. Hepatic lipogenic gene expression of peroxisome proliferator activated receptor gamma, fatty acid synthase, and diacylglycerol O-acyltransferase 2 was down-regulated by apios supplementation. These results suggest that apios is a healthy food for preventing high-fat diet-induced visceral obesity and fatty liver.
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KEYWORD
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apios, atherogenic index, hepatic lipid, obesity, visceral fat
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